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CS Colloquium 11/25/2013 “Unified Lattice Boltzmann Computation for Patient-specific Hemodynamics in Healthy and Disease

Posted Nov. 25, 2013

Unified Lattice Boltzmann Computation for Patient-specific Hemodynamics in Healthy and Diseased Aorta

Huidan (Whitney) Yu

Department of Mechanical Engineering,

Indiana University-Purdue University Indianapolis, IN

November 25th @ 3:45 p.m. 228 MSB



Computational hemodynamics in diseased human arteries heavily relies on the utilization of commercial software packages. Due to the fact that most CFD software solves Navier-Stokes equations on macroscopic level, the CFD solvers  are usually not on high efficiently parallelized, not adequate to  deal with pulsatility, and not capable to jointly consider non-Newtonian effect, turbulence, and fluid structure interaction thus stops well short of instructive information to aid medical assessment and treatment. We innovatively develop a unified computing platform to simulate patient-specific hemodynamics and flow-vessel interaction using lattice Boltzmann method (LBM), which integrates anatomical-structure extraction from imaging data and numerical simulation in one computation mesh structure, where the LBM solves level set equation for image segmentation and Navier-Stokes equation for fluid dynamics respectively.  The patient-specific vessel geometry, volumetric ratio of solid versus fluid, and the orientation of the boundary obtained with high accuracy seamlessly feed to the numerical simulation needs. In order to better treat the complex geometry, we specifically develop volumetric lattice Boltzmann scheme which strictly satisfies mass conservation when boundary moves. Validation study is on hemodynamics and flow-vessel interaction in healthy and diseased aortas. Flow rate and structure, pressure and vorticity distribution, as well as wall normal and shear stresses, are revealed in both cases.  This computation system is suitable to be paralleled on GPU platform aiming to perform real-time simulation and visualization of blood flow in a human body.



Dr. Huidan (Whitney) Yu joined Mechanical Engineering Department of Indiana University-Purdue University, Indianapolis (IUPUI) as a tenure-track assistant professor in 2011. Prior to this position, she successively completed two PhD programs, Physics at Peking University, China and Aerospace Engineering at Texas A&M University, USA, followed by two postdoctoral research positions at Los Alamos National Laboratory and the Johns Hopkins University. Dr. Yu's research field is in computational fluid dynamics in general with expertise on kinetic based lattice Boltzmann method to model and simulate complex flows involving turbulence. Dr. Yu has extensive research experience in dealing with a variety of fluid and thermal problems applications in energy, biomechanics, atmosphere, etc. She has published more than 50 articles in peer-reviewed journals. Her current research focuses include lattice Boltzmann method for complex patient-specific hemodynamics with flow-structure interactions, non-Newtonian effects, turbulence, and pulsatility, turbulence control through parity time-reversal symmetry, and bubble dynamics in reactive micro-flow.